The idea that most patients with type 2 diabetic nephropathy will die of cardiovascular disease (CVD) before they progress to a stage requiring dialysis is outdated, new Australian research suggests.
At three years follow-up a fifth of patients with significant proteinuria developed end stage renal disease, which was around 2.5 times as common as CVD-related death and 1.5 times that of all cause death.
The findings were in “stark contrast” to those of the UKPDS study, the authors noted, in which CVD death was more common than progression to the next stage of nephropathy.
The change was most likely due to significant improvements in the last two decades in management of CV and renal complications in type 2 diabetes, the Australian and US...
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