Updated clinical practice guidelines have been released by the International Society for Pediatric and Adolescent Diabetes (IPSAD), co-edited by Associate Professor Kim Donaghue from The Children’s Hospital at Westmead.
A guideline on the phases of diabetes in young patients, written by Professor Donaghue with Professor Jennifer Couper, reflects the increased level of knowledge about the genetics and immune processes in the disease. While a range of autoantibodies can be detected in preclinical diabetes, islet autoimmunity can be transient and one raised islet antibody alone has little prognostic value. Some genetic markers confer an increased risk of diabetes, but others are protective.
“Neither screening of any population nor intervention in the preclinical phase should occur outside the context of defined clinical...
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