Women with pre-eclampsia during pregnancy are more likely than other women to have hypothyroidism in late pregnancy or in later years, according to an analysis in the BMJ.
The study authors said that the rise in TSH levels was strongly associated with levels of soluble fms-like tyrosine kinase 1, suggesting that the effect of pre-eclampsia on thyroid function may be mediated by this protein.
They evaluated the association of pre-eclampsia with reduced thyroid function during and after pregnancy using data from a nested case-control study during pregnancy and a second population based study with follow-up after pregnancy.
The case-controlled study followed 141 women who had serum measurements before 21 weeks’ gestation (baseline) and after onset of pre-eclampsia (before delivery), and 141 controls...
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